Further observations on strain sensitivity of Trichomonas vaginalis to metronidazole.

Squires and McFadzean (1962) reviewed the question of strain sensitivity of Trichomonas vaginalis to metronidazole. Since then examinations of the sensitivities of strains isolated from occasional patients who had apparently not responded to treatment with metronidazole have been continued. The results of these examinations are described. It was also thought worth while to examine the strain sensitivities of random cultures of the parasite lest there had been a change which was not as yet reflected by therapeutic failures. At the same time, in view of the observation by Nicol, Evans, McFadzean, and Squires (1966) that organisms of the genus Mimae could "inactivate" the drug, the vaginal flora of these patients were also examined for the presence of organisms capable of inactivating the compound.